Stereotactic radiosurgery alone improves survival for patients with brain metastases from small cell lung cancer
A recently published study undertaken by the University of Colorado Cancer Center found stereotactic radiosurgery without whole-brain radiation therapy improved survival for patients with brain metastases from small cell lung cancer. They used the National Cancer Database to identify 5,952 patients with small cell lung cancer and brain metastasis at diagnosis and multivariate Cox regression and propensity score matching to determine each treatment’s effect on overall survival (OS) with median follow up at 40 months. Two hundred patients received only stereotactic radiosurgery, whereas 5,752 underwent both radiosurgery and whole-brain radiation therapy. Stereotactic radiosurgery appeared associated with longer median OS than radiosurgery plus whole-brain radiation therapy (10.8 months vs. 7.1 months) with this improvement persisting in a multivariate analysis that controlled for extracranial metastases, comorbidities, race/ethnicity, age and sex. The article can be viewed here.